PLX100040

GSE77107: Single-cell RNA-seq of Ecad positive PyMT bulk tumor cells

Organsim mouse
Type RNASEQ
Target gene
Project ARCHS4

In this study we studied the presence of tumor cells that underwent epithelial-to-mesenchymal transition within polyoma middle T antigen (PyMT) breast tumors. For this we dissociated tumors and isolated Ecad positive tumor cells by FACS sorting. We confirmed that PyMT tumors contain a small set of tumor cells that have undergone EMT in the primary tumor and that E-cadherin can be used as a marker on single cell level for mesenchymal status in this model. SOURCE: Jean-Charles Boisset (j.boisset@hubrecht.eu) - A. van Oudenaarden Hubrecht Institute

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