PLX205935

GSE75851: ILC progenitor CEL-seq

  • Organsim mouse
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

Here we identify the c-kit+ CILP population which generates all ILC subsets including NK cells, and the CD25- ILC2-restricted Sca-1+ CILP. We mapped the transcriptional changes that occur in ILC progenitor commitment identifying new regulatory factors and provide a map for early ILC differentiation. Finally, we mapped the subsequent transcriptional changes that occur in c-kit+ CILP in absence of Id2 and Tcf7, key regulators downstream of Nfil3. SOURCE: Shian Su (su.s@wehi.edu.au) - Ritchie Lab Walter and Eliza Hall Institute of Medical Research

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