PLX213850

GSE73784: Three-dimensional disorganisation of the cancer genome occurs coincident with long range genetic and epigenetic alterations [RNA-seq]

• Organsim human
• Type RNASEQ
• Target gene
• Project ARCHS4

A three-dimensional chromatin state underpins the structural and functional basis of the genome by bringing regulatory elements and genes into close spatial proximity to ensure proper, cell-type specific gene expression profiles. Here, we perform HiC chromosome conformation, ChIP-seq and RNA-seq to investigate how the three-dimensional organization of the cancer genome is disrupted in the context of epigenetic remodelling and atypical gene expression programs. SOURCE: Joanna Achinger-Kawecka (j.achinger@garvan.org.au) - Epigenetics Research Laboratory Garvan Institute of Medical Research