PLX194255

GSE73457: Genome-wide analysis of gene expression in MLL translocation transformed mouse leukemia cell lines

  • Organsim mouse
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

The purpose of this study is to investigate the transcriptional programs as it relates to disease latency initiated by different MLL fusion proteins, including: MLL-AF1p, MLL-AF6, MLL-Gas7, MLL-AF9 and MLL-ENL. Leukemia cell lines were established by transforming kit+ mouse bone marrow cells with retroviruses coding MLL-AF1p, MLL-AF6, MLL-Gas7, MLL-AF9 or MLL-ENL. At early phase after the cell lines were established, cells growing at exponential phase (cell density at 0.5~1x106/ml) were harvested for RNA extraction and sequencing purpose. SOURCE: Andrew,G.,Muntean (andrewmu@umich.edu) - University of Michigan

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