PLX172996

GSE69637: RNA-seq identifies novel lncRNAs involved in vascular smooth muscle cell proliferation

• Organsim human
• Type RNASEQ
• Target gene
• Project ARCHS4

Smooth muscle cell (SMC) phenotypic switching from a contractile to a synthetic state is implicated in diverse vascular pathologies, including neointimal formation. This study was designed to identify lncRNAs that may play a role in vascular pathologies. Primary smooth muscle cells cultured from surplus human saphenous vein tissue were treated with inflammatory and proliferative stimuli, IL1 and PDGF, for 72h and RNA extracted for RNA-sequencing. Using edgeR processed data we found expression of many lncRNAs was altered following treatment and could play a role in vascular disease. SOURCE: Rachel Dakin (rachel.dakin@glasgow.ac.uk) - University of Glasgow