PLX154881

GSE69549: Transcriptome analysis of CD4+ T cells reveals imprint of BACH2 and IFN regulation

• Organsim human
• Type RNASEQ
• Target gene
• Project ARCHS4

We used RNA sequencing to profile over 70 transcriptomes of CD4+ T cells, a cell type crucial for Coeliac Disease CD pathogenesis, in both stimulated and resting samples from individuals with CD and unaffected controls; The data gave us the opportunity to (i) compare gene expression between cases and controls; (ii) specifically assess whether genes that have been genetically associated with the disease were being DE; (iii) and also look for known and novel aspects of pathogenesis in the transcriptome of this specific cellular compartment. SOURCE: Emma,Marie,Quinn (quinne5@tcd.ie) - Genomic Research Trinity College Dublin