PLX138622

GSE68921: Parkin-mediated mitophagy evokes perinatal cardiac mitochondria maturation

Organsim mouse
Type RNASEQ
Target gene
Project ARCHS4

Exclusion of Parkin from mitochondria of perinatal cardiomyocytes interrupts structural and molecular transformations essential to normal perinatal-adult mitochondrial replacement. mRNA-sequencing from cardiac total RNA was performed at P1, P21 and 5-week stages of nontransgenic (ntg) and human-Mfn2-overexpressing (Mfn2wt) hearts, and also of tet-off control (tetoff) and human-Mfn2 T111A/S442A-overexpressing (Mfn2AA) hearts. SOURCE: Scot,J,Matkovich (smatkovich@gmail.com) - Washington University School of Medicine

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