PLX265011

GSE66777: RNA-seq analysis of gene expression patterns responding to TSA treatment during hESC neural differentiation

  • Organsim human
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

We report the differential roles of an HDAC inhibitor-TSA during hESC nerual commitment. In the initiation of hESC differentiation, TSA could inhibit the downregulation of pluripotency genes to maintain pluripotency, whereas in the neural commitment stage, TSA could promote neural gene expression to assist hESC nerual determination. SOURCE: Naihe Jing (njing@sibcb.ac.cn) - State Key Laboratory of Cell Biology Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences

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