PLX238695

GSE65361: Tcf7 biology in mouse beta-cells

  • Organsim mouse
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

We set out to identify differences in the transcriptome influenced by knockout of the transcription factor T-cell factor 7 (Tcf7) in mouse islets. Furthermore, we wanted to determine if metabolic stress (age,diet) influences these changes. Therefore, we compared the islet transcriptome from WT and Tcf7-/- mice both at a young age (8 weeks old) fed a low fat (10%) diet, versus WT and Tcf7-/- mice at an old age (20 weeks old) on a high-fat (45%) diet. SOURCE: Yu LiuJeff Wrana University of Toronto

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