PLX191872

GSE63853: The effect of Ezh2 knockdown in high-grade glioma

  • Organsim mouse
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

To provide further insight about the effects of prolonged Ezh2 inhibition in glioblastoma using preclinical mouse models and doxycycline-inducible shRNAs that mimic the effects of a selective EZH2 inhibitor. We demonstrate that prolonged Ezh2-depletion causes a robust switch in cell fate, including significantly enhanced proliferation and DNA damage repair and activation of part of the pluripotency network, resulting in altered tumor cell identity and tumor progression. SOURCE: Nienke de Vries NKI

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