PLX156986

GSE63420: Massive parallel sequencing uncovers actionable FGFR2-PPHLN1 fusion and ARAF mutations in intrahepatic cholangiocarcinoma

  • Organsim human
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

Intrahepatic cholangiocarcinoma (iCCA) is a fatal bile duct cancer with dismal prognosis and limited therapeutic options. By performing RNA- and exome sequencing analyses we have discovered a novel fusion event, FGFR2-PPHLN1 (16%), and damaging mutations in the ARAF oncogene (11%). SOURCE: Josep,Maria,Llovet Icahn school of Medicine at Mount Sinai

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