PLX142015

GSE63122: Integrin v3 acting as membrane receptor for thyroid hormones mediates angiogenesis in malignant T cells

Organsim human
Type RNASEQ
Target gene
Project ARCHS4

We have found that thyroid hormones (THs), acting as soluble integrin v3 ligands, activate growth-related signaling pathways in T-cell lymphomas (TCL). Specifically, TH-activated v3 integrin signaling promotes TCL proliferation and angiogenesis, in part, via the up-regulation of VEGF. SOURCE: Tharu,M,Fernando (tmf2001@med.cornell.edu) - Ari Melnick Weill Cornell Medical College

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