PLX127456

GSE62689: RNA-sequencing of unstressed and pressure-overloaded C57 mouse hearts with single or combined ablation of PKCdelta and PKCepsilon

  • Organsim mouse
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

Combinatorial ablation of the major cardiac-expressed novel protein kinase C isoforms, PKCdelta and PKCepsilon, in murine cadiac myocytes unmasked functionally redundant growth-limiting effects of these kinases in hemodynamically stressed adult hearts and during normal embryonic cardiac development, mediated in part by shared transcriptional de-repression of ERK and periostin signaling. SOURCE: Scot,J,Matkovich (smatkovich@gmail.com) - Washington University School of Medicine

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