PLX129999

GSE58663: Molecular Mechanisms of Endothelial Hyperpermeability

• Organsim human
• Type RNASEQ
• Target gene
• Project ARCHS4

Vascular permeability reflects changes in the function of the endothelium, its interendothelial junctions and transcellular delivery. Here, we show that common molecular mechanisms exist between VEGF and histamine in regulating vascular hyperpermeability. Crosstalk between downstream signaling of VEGF and histamine receptors are involved in calcium signaling and cell proliferation. Understanding the molecular mechanisms of vascular permeability is crucial in order to reduce vascular hyperpermeability and oedema in various pathological conditions and in VEGF therapy. SOURCE: Minna,U,Kaikkonen (minna.kaikkonen@uef.fi) - University of Eastern Finland