PLX099326

GSE58111: Genome-wide analysis of transcriptome and translatome following eIF4A1 knockdown in MCF7 cells [RNA-Seq]

Organsim human
Type RNASEQ
Target gene
Project ARCHS4

To identify which genes were regulated by mRNA helicase activity, the effect of eIF4A1 knockdown on the MCF7 cell transcriptome and translatome was determined. eIF4A1-dependent mRNAs were highly enriched for several classes of genes with oncogenic potential, which leads to a model whereby dysregulation of mRNA unwinding contribues to the malignant phenotype in breast cancer cells via preferential translation of a subset of genes. SOURCE: Roslin Russell (roslin.russell@cruk.cam.ac.uk) - Cambridge Research Institute, Cancer Research UK

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