PLX090420

GSE57967: LincRNA-p21 Blocks Somatic Cell Reprogramming by Sustaining H3K9me3 and CpG Methylation at Pluripotent Gene Promoters

  • Organsim mouse
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

Through expression profiling and functional screening we have identified the large intergenic non-coding RNA p21 (lincRNA-p21) as a barrier for reprogramming. LincRNA-p21 is induced by p53 but contrary to its role in the DNA damage response it does not promote apoptosis or cell senescence in reprogramming. Instead, lincRNA-p21 associates with the H3K9 methyltransferase Setdb1 and the maintenance DNA methyltransferase Dnmt1 in separate complexes that are facilitated by the RNA binding protein hnRNP-K. SOURCE: Andrew,Paul,Hutchins (andrew@gibh.ac.cn) - Bioinformatics and Genomics Guangzhou Institutes of Biomedicine and Health

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