PLX101852

GSE50927: RNAseq on lungs from WT vs claudin 4 KO mice that underwent ventilator-induced lung injury

  • Organsim mouse
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

WT mice and claudin 4 KO mice were exposed to ventilator-induced lung injury (VILI) for 2 hours. We found that in some Cldn4 KO mice, injury was similar to WT, while in others, injury was higher, as assessed by amount of protein leak into broncho-alveolar lavage fluid. We performed RNAseq to find which genes were responsible for higher injury in Cldn4 KO mice. SOURCE: Zea Borok (zborok@usc.edu) - Borok University of Southern California

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