PLX158594

GSE157507: Lymphatic endothelial cells contribute to blood vessel formation in tumours

  • Organsim mouse
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

Using multicolor lineage tracing, in vivo time-lapse imaging and single cell transcriptional profiling in a mouse glioma model, we identify tumour blood endothelial cells carrying a Csf1r lineage trace. These Csf1r lineage endothelial cells (CLECs) form up to 10% of the tumour vasculature and express endothelial cell markers as well as a unique set of genes that can also be found in single cell transcriptome data of tumour endothelium from various human tumours. SOURCE: Florian Rambow (Florian.Rambow@cme.vib-kuleuven.be) - VIB

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