PLX174096

GSE157433: RNA-seq of Runx3 cKO SFZ/DZ chondrocytes.

  • Organsim mouse
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

Purpose: To demonstrate Runx3's association with organizing the extracellular matrix in SFZ/DZ chondrocytes.; Method: RNA samples were collected from SFZ/DZ chondrocytes of 5-day-old Col2a1-Cre;Runx3fl/fl and Runx3fl/fl mice.; Results: 18 genes were up- or down-regulated by more than 2-fold in the Runx3 knockout in SFZ.; Conclusions: However, genes organizing the extracellular matrix were down-regulated in Runx3 cKO DZ chondrocytes. SOURCE: Kosei Nagata (knagata-tky@umin.ac.jp) - Sensory and Motor System Medicine the University of Tokyo

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