PLX150326

GSE157409: ERG-mediated coregulator complex formation maintains androgen receptor signaling in prostate cancer [Bulk RNA-seq]

  • Organsim mouse
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

We report the effects of ERG on prostate tumorigenesis, ERG-mediated oncogene addiction, and downstream AR signaling pathways. We determined that ERG facilitates AR-signaling and mediates transformation of prostate cells by maintaining coregulator complex formation at AR-bound sites across the genome. SOURCE: Neel Shah (neel_shah@dfci.harvard.edu) - Dana-Farber Cancer Institute

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