PLX070623

GSE154032: HIF1 is an essential regulator of steroidogenesis in the adrenal gland

• Organsim mouse
• Type RNASEQ
• Target gene
• Project ARCHS4

Hormones produced by the adrenal cortex are absolutely essential for numerous processes in living animals. Our research group investigated to what extend the central regulators of deprived oxygen, hypoxia inducible factors (HIFs), contribute to this steroidogenesis. For this, we developed a set of new transgenic mouse lines displaying modified HIF1 and HIF2 levels in cortical cells and revealed that HIF1 exclusively regulates the transcription of a majority of enzymes responsible for the production of glucocorticoids and mineralocorticoids as well as a consequent inflection of cytokines in circulation. These novel tools will be helpful to understand how sustained and chronic changes in adrenocortical hormones can impact during health and disease. SOURCE: Ben Wielockx Institut für Klinische Chemie und Laboratoriumsmedizin