PLX310398

GSE153764: ATF4 regulates MYB to increase g-globin in response to loss of -globin [RNA-seq]

  • Organsim human
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

Boontanrart et al model the cellular stress that occurs upon reduction in -globin in human erythroid cells. Decrease in -globin attenuates the eIF2aP-ATF4 pathway and results in upregulating fetal g-globin. Down-regulation of ATF4 leads to decreased levels of the g-globin repressor MYB through direct binding at the HBS1L-MYB intergenic region. SOURCE: Jacob,Corn,Lab ETH Zurich

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