PLX106744

GSE151936 (human): C9orf72 in myeloid cells suppresses STING-induced inflammation

  • Organsim human
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

In this study we report that loss of C9orf72 expression in myeloid cells drives STING/type I interferon mediated autoimmunity and enhanced tumor immunity in mice. Additionally, we show that the immunophenotypic signature identified in C9orf72-/- mice is present in blood derived macrophages, whole blood and autopsy brain tissue from C9orf72 repeat expansion ALS/FTD patients. SOURCE: Robert BalohBaloh Cedars-Sinai Medical Center

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