PLX006532

GSE151628: Hand2-Induced Preservation of Sympathetic Neurons Prevents Sarcopenia with Aging

Organsim mouse
Type RNASEQ
Target gene
Project ARCHS4

We examined age-dependent expression of the heart and neural crest derivative 2(Hand2), a critical transcription factor for post mitotic maintenance of SNs, and tested the possibility that inducing its expression exclusively in SNs will significantly prevent (a) motor denervation, (b) impaired NMJ transmission, and (d) loss of muscle mass and function in old mice SOURCE: Willard Freeman (wfreeman@ouhsc.edu) - University of Oklahoma Health Sciences Center

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