PLX303564

GSE150350: TEX15 is an essential executor of MIWI2-directed transposon DNA methylation and silencing.

Organsim mouse
Type RNASEQ
Target gene
Project ARCHS4

The PIWI protein MIWI2 and its associated PIWI-interacting RNAs (piRNAs) instruct DNA methylation of young active transposable elements (TEs) in the male germline. Here we show that MIWI2 associates with TEX15 in foetal gonocytes. TEX15 is predominantly a nuclear protein that is not required for piRNA biogenesis but is essential for piRNA-directed TE de novo methylation and silencing. In summary, TEX15 is an essential executor of mammalian piRNA-directed DNA methylation. SOURCE: Yuka Kabayama (yuka.kabayama@ed.ac.uk) - O'Carroll group University of Edinburgh

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