PLX269580

GSE149203: Neurog3 gene dosage effect on the differentiaiton of intestinal enteroendocrine progenitors

Organsim mouse
Type RNASEQ
Target gene
Project ARCHS4

Analysis of FACS-sorted intestinal Neurog3+/+ and Neurog3+/- cells from Neurog3 fluorencent reporter mice carrying two-(+/+) or one- (+/-) Neurog3 alleles. In the intestine, Neurog3 is an enteroendocrine (EE) lineage determinating transcription factor that transiently expressed in early EEC progenitors. By comparison the molecular profiles of Neurog3+/+ and Neurog3+/- cells, we hypothesized that Neurog3 gene dosage regulates the allocation of EE progenitor fates towards EEC vs. goblet cells. SOURCE: Alper Kucukural (alper.kucukural@umassmed.edu) - Biocore UMass Medical School

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