PLX276242

GSE146673: Mutant huntingtin stalls ribosomes and represses protein synthesis independent of Fragile X mental retardation protein [RNA-seq]

Organsim mouse
Type RNASEQ
Target gene
Project ARCHS4

Huntingtin (Htt) and its poly-Q expanded form, mHtt, causes Huntington disease (HD) and promotes ribosome stalling, suppresses protein synthesis in vivo and in vitro. SOURCE: Srinivasa Subramaniam (ssubrama@scripps.edu) - The Scripps Research Institute

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