PLX178897

GSE146066: Impact of sustained TGF-receptor inhibition on chromatin accessibility and gene expression in cultured endometrial MSC [RNA-Seq]

• Organsim human
• Type RNASEQ
• Target gene
• Project ARCHS4

Endometrial mesenchymal stem cells (eMSC) drive the extraordinary regenerative capacity of the human endometrium. Clinical application of eMSC for therapeutic purposes is hampered by spontaneous differentiation and cellular senescence upon large-scale expansion in vitro. A83-01, a selective TGFbeta receptor inhibitor, promotes pharmacological expansion of eMSC in culture by blocking differentiation and senescence. We subjected primary eMSC treated with A83-01 to RNA sequencing (RNA-seq) to map the underlying gene expression changes. RNA-seq analysis demonstrated that sustained TGFbeta-R inhibition results in differential expression of 1,463 genes. SOURCE: Shanti Gurung (shanti.gurung@hudson.org.au) - Hudson Institute of Medical Research