PLX126078

GSE145797: Conversion of fibroblasts to functional Leydig like cells using defined small molecules

  • Organsim mouse
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

we report that fibroblasts can be efficiently and directly reprogrammed into Leydig-like cells by exposing to a combination of small molecules, Forskolin, 20-hydroxycholesterol, luteinizing hormone (LH), and SB431542. The chemical compounds induced Leydig-like cells (CiLCs) expressed steroidogenic genes, had a global gene expression profile similar to that of Leydig cell, and acquired androgen synthesis capabilities. SOURCE: Chengxing Zhou (zhou.chengxing@outlook.com) - Jinan University

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