PLX045862
GSE145053: Cortical kidney bulk RNA Sequencing in the reversible unilateral ureter obstruction model.
- Organsim mouse
- Type RNASEQ
- Target gene
- Project ARCHS4
The kidney has limited capacity to regenerate following injury and preferentially repairs chronic injury with secreted extracellular matrix proteins. This can be a progressive process with functioning kidney tissue being replaced detrimentally with fibrotic scar tissue, ultimately leading to kidney failure. Using the reversible unilateral ureteric obstruction model, a model of reversable injury, we describe the transcriptomic changes that occur during obstructive renal injury and subsequent repair. SOURCE: Laura Denby (laura.denby@ed.ac.uk) - University of Edinburgh
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