PLX226271

GSE144093: RNA-seq analysis of transcriptomes in control and LAMP2A-overexpressed D3 ES cells

Organsim mouse
Type RNASEQ
Target gene
Project ARCHS4

The role of autophagy and metabolism in regulating the pluripotency of stem cells is not well understood. LAMP2A is a key gene in CMA. Here we compared transcriptomic changes in LAMP2A-overexpressed D3 versus control cells, as well as changes in LAMP2A-overexpressed cells with versus without DM-KG treatment (4mM, 72 hrs). We found that overexpression of LAMP2A leads to decreased expression of genes related to stem cell differentiation, and this can be largely restored by DM-KG supplement. This study provides a promising link for autophagy, metabolism, and pluripotency of stem cells. SOURCE: Xiaolu Yang University of Pennsylvania

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