PLX167983

GSE143743: Knocking out C9ORF72 exacerbates axonal trafficking defects associated with hexanucleotide repeat expansion and reduces levels of heat shock proteins I

  • Organsim human
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

iPSCs with mutant C9ORF72 were edited using CRISPR/Cas9 (1) to knockout C9ORF72 or, alternatively, (2) to correct the ALS mutation, followed by differentiation into motor neurons. SOURCE: Jared Sterneckert (Jared.Sterneckert@tu-dresden.de) - iPS Cells and Neurodegenerative Disease TU Dresden

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