PLX051900

GSE142560 (mouse): Gene expression profile of HSPC with cell-intrinsic innate immune signaling activation after LPS treatment

• Organsim mouse
• Type RNASEQ
• Target gene
• Project ARCHS4

The underlying mechanisms responsible for the competitive advantage of MDS HSPC in an inflammatory milieu remains poorly defined. Here, we show that MDS HPSC are protected from low-grade chronic inflammation, and that the adaptive response of these cells to the inflammatory milieu via the non-canonical NF-B pathway contributes to sustained myeloid expansion and a competitive advantage. These findings uncover the mechanistic basis for the clonal dominance of functionally impaired MDS HSPC and reveal the therapeutic potential of interfering with non-canonical NF-B signaling. SOURCE: Kwangmin Choi Cincinnati Children's Hospital Medical Center