PLX081114

GSE140763: CBX4 role in U2OS/MTX300

  • Organsim human
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

In our study, we found that CBX4 was critical to osteosarcoma metastasis.CBX4, also known as polycomb 2 (Pc2), belongs to the CBX protein family, including CBX2, 4, 6, 7, and 8, which has been shown to participate in the polycomb repressive complex 1 (PRC1) and characterized as a transcriptional repressor. To identify the downstream target genes of CBX4 in osteosarcoma, we conducted the RNA-seq analysis of CBX4 overexpression or knockdown in osteosarcoma cell line U2OS/MTX300. SOURCE: Xin Wang (wangxin1@sysucc.org.cn) - Sun Yat-sen University Cancer Center

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