PLX067903

GSE140689: Direct induction of retinal ganglion cell-like neurons

Organsim mouse
Type RNASEQ
Target gene
Project ARCHS4

Retinal ganglion cells (RGCs) are the projection neurons in the retina that connect the visual sensing tissue to the brain. We found that Ascl1/Brn3b/Isl1 transcription factor combination can quickly and efficiently reprogramming mouse embryonic fibroblasts (MEFs) into retinal ganglion cell-like neurons (iRGCs). Using RNA-seq, we analyzed the transcriptomes of MEFs infected with Ascl1/Brn3b/Isl1-overexpressing viruses on day 2 or day 7 of reprogramming, or the final iRGCs on day 13 of reprogramming. SOURCE: SHUYI CHEN (chenshy23@mail.sysu.edu.cn) - Zhongshan Ophthalmic Center, SYSU

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