PLX032695

GSE140495: In vivo CRISPR screens reveal NOTCH regulators suppressing Head and Neck Squamous Cell Carcinoma in mice [RNA-seq]

  • Organsim mouse
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

In most cancers, only a few genes are mutated at high frequencies, while the vast majority are mutated at low frequencies. The functions of these recurrent but infrequent long-tail mutations remain largely elusive. Here, we develop in vivo CRISPR screens to assess the transforming potential of 484 long-tail genes in human Head and Neck Squamous Cell 5 Carcinoma (HNSCC). SOURCE: Daniel Schramek (schramek@lunenfeld.ca) - Schramek Lab Lunenfeld- Tanenbaum Research Institute

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