PLX020159

GSE140472: ZBTB7A prevents RUNX1-RUNX1T1 dependent clonal expansion of human hematopoietic progenitor cells

Organsim human
Type RNASEQ
Target gene
Project ARCHS4

ZBTB7A is frequently mutated in acute myeloid leukemia (AML) with t(8;21) translocation. However, the oncogenic collaboration between mutated ZBTB7A and the RUNX1-RUNX1T1 fusion gene in AML t(8;21) remains unclear. Here, we investigate the role of ZBTB7A and its mutations in the context of normal and malignant hematopoiesis. SOURCE: Enric Redondo Monte (e.redondo@campus.lmu.de) - Ludwig-Maximilians University Munich

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