PLX012074

GSE140471: Transcriptomic analysis of CIC and ATXN1L in normal human astrocytes

  • Organsim human
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

Aberrations in Capicua (CIC) have recently been implicated as a negative prognostic factor in a multitude of cancer types through activation of the MAPK signalling cascade and derepression of oncogenic ETS transcription factors. The Ataxin-family protein ATXN1L has previously been reported to interact with CIC in developmental and disease contexts to facilitate the repression of CIC target genes. To further investigate this relationship, we performed functional in vitro studies utilizing ATXN1LKOand CICKOhuman cell lines and characterized a reciprocal functional relationship between CIC and ATXN1L. SOURCE: Derek Wong (dwong@bccrc.ca) - Stephen Yip University of British Columbia

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