PLX301111

GSE140026 (mouse): GCN2 drives macrophage and MDSC function and immunosuppression in the tumor microenvironment [RNA-Seq]

  • Organsim mouse
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

The purpose of our study was to examine the role of GCN2 in the function of immunosuppressive cells such as tumor associated macrophages and MDSCs. We show that a myeloid lineage specific deletion of GCN2 results in a shift towards a more proinflammatory phenotype of tumor associated macrophages and MDSCs, thereby promoting anti-tumor immunity. SOURCE: Andreas Kloetgen NYU School of Medicine

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