PLX285068

GSE138938: -catenin regulates FOXP2 transcriptional activity via multiple binding sites

Organsim human
Type RNASEQ
Target gene
Project ARCHS4

We observed different gene expression by overexpressing the transcription factor FOXP2 in U2OS cells compared to mock-transfected cells. Additionally, we found -catenin as co-activator binding directly to FOXP2. Activation of Wnt signaling was changing the transcriptional activity of FOXP2. Other functional and regulatory elements were found within FOXP2 and were confirmed by RNA-Seq. SOURCE: Gesa Richter (gesa.richter@medunigraz.at) - Medical University Graz

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