PLX223724

GSE138729 (human): Induction of extracellular adenosine salvage and metabolic quiescence regulate the transitional to follicular B cell checkpoint in humans.

  • Organsim human
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

Transcriptional profiling of transitional and follicular B cells showed that metabolic quiescence was acquired at the follicular B cell stage in both humans and mice, characterized by an orchestrated reduction of mTORC1 signaling, aerobic respiration and expression of genes involved in ribosome biogenesis. SOURCE: Vinay Mahajan Ragon Institute of MGH, MIT and Harvard

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