PLX010564

GSE138026: Cytosolic phospholipase A2 alpha regulates TLR signaling and migration in metastatic 4T1 cells

Organsim mouse
Type RNASEQ
Target gene
Project ARCHS4

We aimed at characterizing the response to reduced cPLA2 activity in metastatic versus non-metastatic cells.; We employed an isogenic murine cell line pair displaying metastatic (4T1) and non-metastatic (67NR) phenotype to investigate the role of cPLA2 on migration. Further, we elucidate the effect of reduced cPLA2 activity on global gene expression in the metastatic cell line; We found that cPLA2 inhibition may inhibit metastasis through an anti-migratory effect, possibly involving Toll-like receptor signaling and type I interferons SOURCE: Hanna Maja TunsetMR Cancer NTNU

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