PLX030381

GSE138010: Fosl1 regulates mesenchymal GBM plasticity

  • Organsim mouse
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

Despite recent advances in genomic profiling techniques, the precise mechanisms controlling GBM subtypes and their plasticity are not fully unraveled. Here,using transcriptomic data of patient derived stem cell lines we found that FOSL1 is a master regulator of the MES subtype. Depletion of FOSL1 resulted in loss of themesenchymal gene signature (MGS) in mouse Kras-mutant neural stem cells and in human brain tumor stem cells. SOURCE: Massimo Squatrito (msquatrito@cnio.es) - Spanish National Research Center (CNIO)

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