PLX180138

GSE137426: The fibronectin mediated endothelial rescue effect in CCM3-deficient cells is independent from acute mRNA changes

  • Organsim human
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

Using CRISPR/Cas9 genome editing and RNA sequencing, we demonstrate that fibronectin supplementation restores the impaired spheroid formation and attenuates actin stress fiber assembly in CCM3-/- endothelial cells independently of acute gene expression differences. In particular, there was no significant downregulation of well-known key players in CCM pathogenesis like KLF2 or KLF4. SOURCE: Matthias Rath (rathm@uni-greifswald.de) - University Medicine Greifswald

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