PLX194804

GSE137425: mRNA expression changes in CCM3-deficient endothelial cells

  • Organsim human
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

Loss-of-function variants in CCM3/PDCD10 predispose to cerebral cavernous malformations (CCMs) that are vascular lesion of the central nervous system. Using CRISPR/Cas9 genome editing and RNA sequencing, we have shown that long-term inactivation of CCM3 in human endothelial cells dysregulates fibronectin expression and thus impairs the assembly of a functional fibronectin matrix by endothelial cells. SOURCE: Matthias Rath (rathm@uni-greifswald.de) - University Medicine Greifswald

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