PLX298501

GSE136928: Identification of miRNA-mRNA regulatory network for Human Atrial Aging [mRNA]

• Organsim human
• Type RNASEQ
• Target gene
• Project ARCHS4

We report an integrative analysis of miRNA-seq and mRNA-seq to identify miRNAs, genes, and miRNA-mRNA interactions for human atrial aging (AA). We found that seven miRNAs (4 upregulation and 3 downregulation) and 42 genes (23 upregulation and 19 downregulation) show differential expression between older samples and younger samples in human right atrial tissues. Pearson correlation analysis identified 114 pairs of putative miRNA-mRNA interactions for AA. Pathway enrichment analysis identified three important pathways including rhythmic process, senescence and autophagy in cancer, and positive regulation of cytokine biosynthetic process. Our study revealed novel miRNA-mRNA interaction networks and signaling pathways for AA, providing novel insights into the development of human AA. This dataset includes data generation and processing steps for the mRNA-seq data generated from twelve SR samples. SOURCE: Yan Yao (iceyaya614@126.com) - Beijing Anzhen Hospital