PLX297131

GSE136884: The impact of stanniocalcin 1 on the transcriptome of human cord blood stem/progenitors

Organsim human
Type RNASEQ
Target gene
Project ARCHS4

Purpose: Stanniocalcin 1 (STC1) is a secreted glycoprotein expressed in mesenchymal stroma cells (MSCs). STC1 expression is upregulated in response to acute myeloid leukemia (AML) co-culture. Recombinant STC1 has proliferation limiting effects on human hematopoietic stem/progenitors cells (HSPCs) and facilitiates the preservation of HSCs ex vivo. We hope to gain insight into the mechanism by exploring the transcriptome of stem/progenitors exposed to STC1. SOURCE: Dominique BonnetHaematopoietic Stem Cell Lab Francis Crick Institute

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