PLX296921

GSE136866: Sestrin prevents skeletal muscle atrophy

Organsim mouse
Type RNASEQ
Target gene
Project ARCHS4

We identify sestrins, a family of stress-inducible metabolic regulators, as protective factors against muscle wasting. Sestrin expression decreases during inactivity and its genetic deficiency exacerbates muscle wasting; conversely, sestrin overexpression suffices to prevent atrophy. SOURCE: Eusebio Perdiguero (eusebio.perdiguero@upf.edu) - Cell Biology UPF

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