PLX158043

GSE136022: Genome-wide view of the impact of Spt5-Pol II inhibitors (SPIs) on mRNA levels [RNA-Seq 2h]

  • Organsim human
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

We identified the first Spt5-Pol II inhibitors (SPIs). SPIs faithfully reproduced Spt5 knockdown effects on proximal-promoter-pausing, NF-B activation and the expanded-repeat huntingtin gene in neuronal cells. We determined the global effect of short and long-term SPI-21 treatment by RNA-seq and compared the affected genes between the two treatments. The results revealed that temporary and constitutive Spt5-regulated genes can be distinguished by SPIs. SOURCE: Dena Leshkowitz (dena.leshkowitz@weizmann.ac.il) - Weizmann Institute of Science

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