PLX011512

GSE135330: Microglial microRNAs mediate sex-specific responses to tau pathology

  • Organsim mouse
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

Sex is a key modifier of neurological disease outcomes. Microglia are implicated in neurological diseases and modulated by miRNAs, but it is unknown whether microglial miRNAs have sex-specific influences on disease. We show that microglial miRNA expression differs in males and females, and loss of miRNAs leads to sex-specific changes in the microglial transcriptome and to tau pathology. These findings suggest microglial miRNAs influence tau pathogenesis in a sex-specific manner. SOURCE: Lay Kodama (lay.kodama@gladstone.ucsf.edu) - University of California San Francisco

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